The Department started in 2002 when the University commenced. Computer Science and Management Information System programmes were under the then Department of Computer and Information Technology with Prof. T.S. Ibiyemi as the Head of the Department. The pioneer faculty in the Department were Mr. V. C. Osamor, Mr. Nicholas A. Omoregbe and Mr. O. O. Olugbara. In 2003, Dr. C. K. Ayo joined the University and became the first substantive Head of Department. Dr. E. F. Adebiyi was the Head of Department from 2008-2011. Also, Prof. C. K. Ayo became the Head of Department from 2011-2012 after serving as the Director of Academic planning. Dr. Nicholas A. Omoregbe assumed the office as Head of the Department of Computer and Information Sciences in 2012. Dr. A. A. Adebiyi became the Head of Department from 2014 – 2016. Dr. O. O. Oladipupo became the Head of Department from 2016-2017. In August 2017, the headship of the Department of Computer and Information Science (CIS) witnessed the emergence of a pioneer faculty in the person of Dr V.C. Osamor to pilot the affairs of this strategic Department. Dr V.C. Osamor has since assumed this leadership role as the current HOD, CIS. The Department which started with 13 faculty has produced several graduates at B.Sc, M.Sc and Ph.D levels.